Sensorimotor and inhibitory control in aging FMR1 premutation carriers.

ABSTRACT: Aging FMR1 premutation carriers are at risk of developing neurodegenerative disorders, including fragile X-associated tremor/ataxia syndrome (FXTAS), and there is a need to identify biomarkers that can aid in identification and treatment of these disorders. While FXTAS is more common in males than females, females can develop the disease, and some evidence suggests that patterns of impairment may differ across sexes. Few studies include females with symptoms of FXTAS, and as a result, little information is available on key phenotypes for tracking disease risk and progression in female premutation carriers. Our aim was to examine quantitative motor and cognitive traits in aging premutation carriers. We administered oculomotor tests of visually guided/reactive saccades (motor) and ant

SUBMITTER: Fielding-Gebhardt H 

PROVIDER: S-EPMC10687573 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature