Early-in-life isoflurane exposure alters resting-state functional connectivity in juvenile non-human primates.

ABSTRACT:

Background

Clinical studies suggest that anaesthesia exposure early in life affects neurobehavioural development. We designed a non-human primate (NHP) study to evaluate cognitive, behavioural, and brain functional and structural alterations after isoflurane exposure during infancy. These NHPs displayed decreased close social behaviour and increased astrogliosis in specific brain regions, most notably in the amygdala. Here we hypothesise that resting-state functional connectivity MRI can detect alterations in connectivity of brain areas that relate to these social behaviours and astrogliosis.

Methods

Imaging was performed in 2-yr-old NHPs under light anaesthesia, after early-in-life (postnatal days 6-12) exposure to 5 h of isoflurane either one or three times, or to room air

SUBMITTER: Neudecker V 

PROVIDER: S-EPMC10687619 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature