Plasma Biomarkers of Alzheimer Disease in Women With and Without HIV.

ABSTRACT:

Importance

Blood-based biomarkers associated with increased risk of Alzheimer disease (AD) are understudied in people living with and without HIV, particularly women.

Objective

To determine whether baseline or 1-year changes in plasma amyloid-β40 (Aβ40), Aβ42, ratio of Aβ42 to Aβ40, total tau (t-tau), phosphorylated tau 231 (p-tau231), glial fibrillary acidic protein (GFAP), and/or neurofilament light chain (NFL) are associated with neuropsychological performance (NP) among women living with HIV (WLWH) and women living without HIV (WLWOH).

Design, setting, and participants

This longitudinal, prospective, cohort study with 1-year repeated clinical measures (NP only measured once) and biospecimen collection occurred between 2017 and 2019. Participants were women aged 40

SUBMITTER: Li X 

PROVIDER: S-EPMC10687654 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature