Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson's disease.

ABSTRACT: Parkinson's disease pathology is hypothesized to spread through the brain via axonal connections between regions and is further modulated by local vulnerabilities within those regions. The resulting changes to brain morphology have previously been demonstrated in both prodromal and de novo Parkinson's disease patients. However, it remains unclear whether the pattern of atrophy progression in Parkinson's disease over time is similarly explained by network-based spreading and local vulnerability. We address this gap by mapping the trajectory of cortical atrophy rates in a large, multi-centre cohort of Parkinson's disease patients and relate this atrophy progression pattern to network architecture and gene expression profiles. Across 4-year follow-up visits, increased atrophy rates were obser

SUBMITTER: Vo A 

PROVIDER: S-EPMC10687705 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature