Network and Computational Drug Repurposing Analysis for c-Myc Inhibition in Burkitt Lymphoma.

ABSTRACT:

Background/aim

The treatment rate of Burkitt lymphoma (BL) is still low in low-income countries and among elderly patients. The c-Myc dysregulation induced by mutations is one of the characteristics of BL. However, studies on the downstream signaling pathways of c-Myc are still lacking. This study aimed to identify the signaling pathways regulated by c-Myc.

Materials and methods

Network and gene set analyses using c-Myc inhibition (i.e., c-Myc knock-down and c-Myc inhibitor treatment) transcriptome datasets for BL cell lines were performed to determine the pathways regulated by c-Myc. In addition, computational drug repurposing was used to identify drugs that can regulate c-Myc downstream signaling pathway.

Results

Computational drug repurposing revealed that the ERK/

SUBMITTER: Lee Y 

PROVIDER: S-EPMC10687731 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature