Relapse recovery in relapsing-remitting multiple sclerosis: An analysis of the CombiRx dataset.

ABSTRACT:

Background

Clinical relapses are the defining feature of relapsing forms of multiple sclerosis (MS), but relatively little is known about the time course of relapse recovery.

Objective

The aim of this study was to investigate the time course of and patient factors associated with the speed and success of relapse recovery in people with relapsing-remitting MS (RRMS).

Methods

Using data from CombiRx, a large RRMS trial (clinicaltrials.gov identifier NCT00211887), we measured the time to recovery from the first on-trial relapse. We used Kaplan-Meier survival analyses and Cox regression models to investigate the association of patient factors with the time to unconfirmed and confirmed relapse recovery.

Results

CombiRx included 1008 participants. We investigated 240

SUBMITTER: Koch MW 

PROVIDER: S-EPMC10687796 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature