Dataset Information

Vaccination frequency in people newly diagnosed with multiple sclerosis.

ABSTRACT:

Background

Infections are discussed as risk factor for multiple sclerosis (MS) development and relapses. This may lead to decreased vaccination frequency in newly diagnosed patients.

Objective

The aim of this study was to evaluate the relation of MS diagnosis to subsequent vaccination frequency.

Methods

Based on German ambulatory claims data from 2005 to 2019, regression models were used to assess the relation of MS diagnosis (n = 12,270) to vaccination. A cohort of patients with MS was compared to control cohorts with Crohn's disease, psoriasis, and without these autoimmune diseases (total n = 198,126) in the 5 years after and before diagnosis.

Results

Patients with MS were less likely to be vaccinated compared to persons without the autoimmune diseases 5 years after diagnosis (odds ratio = 0.91, p < 0.001). Exceptions were vaccinations against influenza (1.29, p < 0.001) and pneumococci (1.41, p < 0.001). Differences were strong but less pronounced after than before diagnosis (p < 0.001). The likelihood of vaccination was also lower compared to patients with Crohn's disease or psoriasis.

Conclusions

Patients with MS were not adequately vaccinated despite guideline recommendations. Increasing awareness about the importance of vaccination is warranted to reduce the risk of infection, in particular, in patients with MS receiving immunotherapies.

SUBMITTER: Darvishi S

PROVIDER: S-EPMC10687801 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Vaccination frequency in people newly diagnosed with multiple sclerosis.

Darvishi Sonia S Donnachie Ewan E Gasperi Christiane C Hapfelmeier Alexander A Hemmer Bernhard B

Multiple sclerosis (Houndmills, Basingstoke, England) 20231013 14

<h4>Background</h4>Infections are discussed as risk factor for multiple sclerosis (MS) development and relapses. This may lead to decreased vaccination frequency in newly diagnosed patients.<h4>Objective</h4>The aim of this study was to evaluate the relation of MS diagnosis to subsequent vaccination frequency.<h4>Methods</h4>Based on German ambulatory claims data from 2005 to 2019, regression models were used to assess the relation of MS diagnosis (<i>n</i> = 12,270) to vaccination. A cohort of ...[more]

PMID: 37830337

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Project description:BackgroundPeople newly diagnosed with multiple sclerosis (MS) often pursue 'health-related' behaviour changes to feel in control of their diagnosis. However, little is known about the specific factors that may influence behaviour change during this crucial time. Therefore, we conducted an in-depth exploration of the socioecological influences impacting the diagnostic experience and self-management practices following an MS diagnosis.MethodsWe followed a qualitative study design using a phenomenological approach to explore the lived experiences of people newly diagnosed with MS. Analysis was conducted via an iterative process, starting with deductive open coding to map onto the socioecological model, followed by inductive focused coding to extract key themes from participants' reported experiences.ResultsEight participants diagnosed with MS within the past 12 months were interviewed. Four themes were reported across the MS journey, reflecting the different levels of the socioecological model: (1) taking control of a new diagnosis to retain a sense of personal identity-individual level; (2) grief and acceptance guided by community-social connection, community and social environment; (3) practical management of MS in the wider society-policy and government regulation; and (4) global events that greatly upheave the MS journey-natural disasters and societal conflicts, such as a pandemic. These themes highlighted the complex interrelationship between socioecological factors and self-management abilities in people living with MS.ConclusionsThe diagnostic experience of those with MS is highly complex. Although it varies for each person living with MS, there are shared experiences that often reflect a common cycle of grief. An MS diagnosis provides an opportunity for self-rediscovery, which can both influence and be influenced by socioecological factors. The social and technical nature of self-managing MS strongly shapes the diagnostic experience, underpinning many aspects of daily living, social interaction and physical and psychological well-being.Patient or public contributionThe research team worked closely with an MS-specific consumer panel for the study design. This project was raised with this group, and preliminary results were shared at a national conference for MS during a lived-experience consumer stream to gain additional insights.

Dataset Information

Vaccination frequency in people newly diagnosed with multiple sclerosis.

Background

Objective

Methods

Results

Conclusions

Publications

Vaccination frequency in people newly diagnosed with multiple sclerosis.

Similar Datasets

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