An association between ATP7B expression and human cancer prognosis and immunotherapy: a pan-cancer perspective.

ABSTRACT:

Background

ATP7B is a copper-transporting protein that contributes to the chemo-resistance of human cancer cells. It remains unclear what the molecular mechanisms behind ATP7B are in cancer, as well as its role in human pan-cancer studies.

Methods

Our study evaluated the differential expression of ATP7B in cancer and paracancerous tissues based on RNA sequencing data from the GTEx and TCGA. Kaplan-Meier and Cox proportional hazards regressions were used to estimate prognostic factors associated with ATP7B.The correlations between the expression of ATP7B and immune cell infiltration, tumor mutation burden, microsatellite instability and immune checkpoint molecules were analyzed. Co-expression networks and mutations in ATP7B were analyzed using the web tools. An analysis of AT

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10687837 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature