Salivary microbiome changes distinguish response to chemoradiotherapy in patients with oral cancer.

ABSTRACT:

Background

Oral squamous cell carcinoma (SCC) is associated with oral microbial dysbiosis. In this unique study, we compared pre- to post-treatment salivary microbiome in patients with SCC by 16S rRNA gene sequencing and examined how microbiome changes correlated with the expression of an anti-microbial protein.

Results

Treatment of SCC was associated with a reduction in overall bacterial richness and diversity. There were significant changes in the microbial community structure, including a decrease in the abundance of Porphyromonaceae and Prevotellaceae and an increase in Lactobacillaceae. There were also significant changes in the microbial community structure before and after treatment with chemoradiotherapy, but not with surgery alone. In patients treated with chemoradi

SUBMITTER: Medeiros MC 

PROVIDER: S-EPMC10687843 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature