Dissemination feature based on PET/CT is a risk factor for diffuse large B cell lymphoma patients outcome.

ABSTRACT:

Background

¹⁸F-FDG PET/CT provides precise information about dissemination of lymphoma lesions. Dmax, defined as distance between the two lesions that were farthest apart by PET/CT, was found to be a promising predictor of Diffuse large B-cell lymphoma (DLBCL) outcome in a small size of clinical trial data. We analyzed the impact of Dmax on the outcome of a large real-world DLBCL cohort.

Methods

Data of newly diagnosed DLBCL at the Third Affiliated Hospital of Soochow University were retrospectively collected. Baseline Dmax, clinical data and survival information were recorded. A metabolic parameter, metabolic bulk volume (MBV), was also measured to verify the independent impact of Dmax.

Results

Optimal cut-off values for Dmax and MBV were 45.34 cm and 21.6

SUBMITTER: Wang F 

PROVIDER: S-EPMC10687880 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature