Urinary Copper Excretion Is Associated with Long-Term Graft Failure in Kidney Transplant Recipients.

ABSTRACT:

Introduction

In chronic kidney disease, proteinuria increases urinary copper excretion, inducing oxidative tubular damage and worsening kidney function. We investigated whether this phenomenon occurred in kidney transplant recipients (KTRs). In addition, we studied the associations of urinary copper excretion with the biomarker of oxidative tubular damage urinary liver-type fatty-acid binding protein (u-LFABP) and death-censored graft failure.

Methods

This prospective cohort study was performed in the Netherlands between 2008 and 2017, including outpatient KTR with a functioning graft for longer than 1 year, who were extensively phenotyped at baseline. Twenty-four-hour urinary copper excretion was measured by inductively coupled plasma mass spectrometry. Multivariable linear

SUBMITTER: Yepes-Calderon M 

PROVIDER: S-EPMC10687917 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature