Causal effects of gut microbiome on endometriosis: a two-sample mendelian randomization study.

ABSTRACT:

Background

Previous studies have shown observational associations between the gut microbiota and endometriosis; however, the causal nature of such associations remains unclear. This study aimed to analyze the genetic causal relationship between the two.

Methods

A gut microbiome genome-wide association study conducted by the MiBioGen consortium was used as exposure data, and summary statistics of endometriosis were obtained from the FinnGen consortium R8 release data. Inverse variance weighted, MR-Egger, weighted median, weighted model, and simple model analyses were applied to examine the causal relationship, and sensitivity analyses were conducted to validate the robustness of the results.

Results

The results showed that, out of 211 gut microbiome taxa, Clostridiales

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10687921 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature