Detection of Inflammatory Biomarker suPAR in COVID-19 Disease With CHORUS TRIO Instrument.

ABSTRACT:

Background

Deregulation in the urokinase-type plasminogen activator receptor (uPA/uPAR) system is reported in many diseases where the immune system is activated. During SARS-CoV-2 infection, a rise in soluble uPAR (suPAR) levels has been detected and its concentration above 6 µg/L predicts worsening to severe respiratory failure 14 days earlier, with a positive predictive value of 85.9%, and was the prerequisite for a treatment with anakinra, a recombinant IL-1 receptor antagonist that blocks the activity of both IL-1α and IL-1β.

Objectives

To compare suPAR concentrations measured by CHORUS suPAR on CHORUS TRIO instrument of DIESSE with the commercially available suPARnostic (ViroGates) ELISA assay.

Design

A single-centre, non-pharmacological, diagnostic study was per

SUBMITTER: Helena C 

PROVIDER: S-EPMC10687937 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature