Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma.

ABSTRACT:

Background

Renal cancer therapies are challenging owing to the extensive spreading of this cancer to other organs and its ability to pose resistance to current medications. Therefore, drugs targeting novel targets are urgently required to overcome these challenges. The cholesterol side-chain cleavage enzyme (CYP11A1) is closely associated with steroidogenesis, and its downregulation is linked to adrenal dysfunction and several types of carcinoma. We previously found that overexpression of CYP11A1 inhibited epithelial-mesenchymal transition and induced G2/M arrest in the kidney cancer Caki-1 cell line. In this context, natural compounds that exhibit potent CYP11A1 stimulation activity can be promising therpaeutic agents for kidney cancer.

Methods

We screened a panel of 1374 n

SUBMITTER: Ong HTM 

PROVIDER: S-EPMC10687993 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature