Changes of gut microbiota and short chain fatty acids in patients with Peutz-Jeghers syndrome.

ABSTRACT: Peutz-Jeghers Syndromeis a rare autosomal dominant genetic disease characterized by gastrointestinal hamartomatous polyps and skin and mucous membrane pigmentation. The pathogenesis of PJS remains unclear; however, it may be associated with mutations in the STK11 gene, and there is currently no effective treatment available. The gut microbiota plays an important role in maintaining intestinal homeostasis in the human body, and an increasing number of studies have reported a relationship between gut microbiota and human health and disease. However, relatively few studies have been conducted on the gut microbiota characteristics of patients with PJS. In this study, we analyzed the characteristics of the gut microbiota of 79 patients with PJS using 16 S sequencing and measured the levels of s

SUBMITTER: Zhou A 

PROVIDER: S-EPMC10688050 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature