GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes.

ABSTRACT:

Background

Heart failure (HF) seriously threatens human health worldwide. However, the pathological mechanisms underlying HF are still not fully clear.

Results

In this study, we performed proteomics and transcriptomics analyses on samples from human HF patients and healthy donors to obtain an overview of the detailed changes in protein and mRNA expression that occur during HF. We found substantial differences in protein expression changes between the atria and ventricles of myocardial tissues from patients with HF. Interestingly, the metabolic state of ventricular tissues was altered in HF samples, and inflammatory pathways were activated in atrial tissues. Through analysis of differentially expressed genes in HF samples, we found that several glutathione S-transferase (GST)

SUBMITTER: Xu H 

PROVIDER: S-EPMC10688053 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature