Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans.

ABSTRACT:

Background

The individual lifestyle and environment of an organism can influence its phenotype and potentially the phenotype of its offspring. The different genetic and non-genetic components of the inheritance system and their mutual interactions are key mechanisms to generate inherited phenotypic changes. Epigenetic changes can be transmitted between generations independently from changes in DNA sequence. In Caenorhabditis elegans, epigenetic differences, i.e. epimutations, mediated by small non-coding RNAs, particularly 22G-RNAs, as well as chromatin have been identified, and their average persistence is three to five generations. In addition, previous research showed that some epimutations had a longer duration and concerned genes that were enriched for multiple components of x

SUBMITTER: Fallet M 

PROVIDER: S-EPMC10688063 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature