Post-insertion technique to introduce targeting moieties in milk exosomes for targeted drug delivery.

ABSTRACT:

Background

Recently, increased attention has been given on exosomes as ideal nanocarriers of drugs owing to their intrinsic properties that facilitate the transport of biomolecular cargos. However, large-scale exosome production remains a major challenge in the clinical application of exosome-based drug delivery systems. Considering its biocompatibility and stability, bovine milk is a suitable natural source for large-scale and stable exosome production. Because the active-targeting ability of drug carriers is essential to maximize therapeutic efficacy and minimize side effects, precise membrane functionalization strategies are required to enable tissue-specific delivery of milk exosomes with difficulty in post-isolation modification.

Methods

In this study, the membrane func

SUBMITTER: Jang H 

PROVIDER: S-EPMC10688116 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature