Phylogenomic assessment of 23 equid alphaherpesvirus 1 isolates obtained from USA-based equids.

ABSTRACT:

Background

Equid alphaherpesvirus 1 (EHV-1) is a global viral pathogen of domestic equids which causes reproductive, respiratory and neurological disease. Few isolates acquired from naturally infected USA-based hosts have been fully sequenced and analyzed to date. An ORF 30 (DNA polymerase) variant (A2254G) has previously been associated with neurological disease in host animals. The purpose of this study was to perform phylogenomic analysis of EHV-1 isolates acquired from USA-based hosts and compare these isolates to previously sequenced global isolates.

Methods

EHV-1 was isolated from 23 naturally infected USA-based equids (6 different states, 15 disease outbreaks) with reproductive (22/23) or neurological disease (1/23). Following virus isolation, EHV-1 DNA was extracted

SUBMITTER: Emelogu U 

PROVIDER: S-EPMC10688130 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature