Antiviral Effects of Pyrroloquinoline Quinone through Redox Catalysis To Prevent Coronavirus Infection.

ABSTRACT: The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease (COVID-19) is ongoing. Therefore, effective prevention of virus infection is required. Pyrroloquinoline quinone (PQQ), a natural compound found in various foods and human breast milk, plays a role in various physiological processes and is associated with health benefits. In this study, we aimed to determine the effects of PQQ on preventing coronavirus infections using a proxy Feline Infectious Peritonitis Virus (FIPV; belongs to the coronavirus family). In plaque reduction assays, we showed that pre- and post-PQQ-treated viruses were less infectious. IC₅₀ was 87.9 and 5.1 μM for pre- and post-PQQ-treated viral infections, respectively. These results suggest that PQQ decreased th

SUBMITTER: Mohamad Ishak NS 

PROVIDER: S-EPMC10688161 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature