Smoking history and breast cancer risk by pathological subtype: MCC-Spain study.

ABSTRACT:

Introduction

The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action.

Methods

In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models.

Results

Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ≥30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk

SUBMITTER: Penalver-Argueso B 

PROVIDER: S-EPMC10688255 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature