Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab.

ABSTRACT:

Background

Recurrent pregnancy loss (RPL) is defined as the failure of two or more clinically recognised pregnancies before 20 weeks of gestation. The prevalence of clinically evident RPL is 1%-2% worldwide. The aetiologies of RPL include uterine anatomic anomalies, uncontrolled diabetes mellitus, untreated hypothyroidism, parental chromosomal abnormalities, antiphospholipid antibody syndrome, thrombophilia, genetic abnormalities and infections.

Aims

This study was aimed at investigating the possible association between CYP11A1 (rs11632698) and (rs4077582) polymorphisms with RPL in the female population of Punjab.

Settings and design

The case- control study was conducted on 170 subjects, of which 80 RPL cases and 90 controls were analysed.

Materials and meth

SUBMITTER: Rayat AK 

PROVIDER: S-EPMC10688282 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature