Sirtuin 1 alleviates alcoholic liver disease by inhibiting HMGB1 acetylation and translocation.

ABSTRACT:

Background

Alcoholic liver disease (ALD) encompasses a spectrum of liver disorders resulting from prolonged alcohol consumption and is influenced by factors such as oxidative stress, inflammation, and apoptosis. High Mobility Group Box 1 (HMGB1) plays a pivotal role in ALD due to its involvement in inflammation and immune responses. Another key factor, Sirtuin 1 (SIRT1), an NAD⁺-dependent deacetylase, is known for its roles in cellular stress responses and metabolic regulation. Despite individual studies on HMGB1 and SIRT1 in ALD, their specific molecular interactions and combined effects on disease advancement remain incompletely understood.

Methods

Alcohol-induced liver injury (ALI) models were established using HepG2 cells and male C57BL/6 mice. HMGB1 and SIRT1

SUBMITTER: Fu J 

PROVIDER: S-EPMC10688304 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature