Adenovirus E1B-55K controls SUMO-dependent degradation of antiviral cellular restriction factors.

ABSTRACT:

Importance

Human adenoviruses (HAdVs) generally cause mild and self-limiting diseases of the upper respiratory and gastrointestinal tracts but pose a serious risk to immunocompromised patients and children. Moreover, they are widely used as vectors for vaccines and vector-based gene therapy approaches. It is therefore vital to thoroughly characterize HAdV gene products and especially HAdV virulence factors. Early region 1B 55 kDa protein (E1B-55K) is a multifunctional HAdV-encoded oncoprotein involved in various viral and cellular pathways that promote viral replication and cell transformation. We analyzed the E1B-55K dependency of SUMOylation, a post-translational protein modification, in infected cells using quantitative proteomics. We found that HAdV increases overall cellular S

SUBMITTER: Ip W-H 

PROVIDER: S-EPMC10688335 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature