Kinetics of severe dengue virus infection and development of gut pathology in mice.

ABSTRACT:

Importance

Dengue virus, an arbovirus, causes an estimated 100 million symptomatic infections annually and is an increasing threat as the mosquito range expands with climate change. Dengue epidemics are a substantial strain on local economies and health infrastructure, and an understanding of what drives severe disease may enable treatments to help reduce hospitalizations. Factors exacerbating dengue disease are debated, but gut-related symptoms are much more frequent in severe than mild cases. Using mouse models of dengue infection, we have shown that inflammation and damage are earlier and more severe in the gut than in other tissues. Additionally, we observed impairment of the gut mucus layer and propose that breakdown of the barrier function exacerbates inflammation and promote

SUBMITTER: Pliego Zamora A 

PROVIDER: S-EPMC10688336 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature