Coxsackievirus A6 2C protein antagonizes IFN-β production through MDA5 and RIG-I depletion.

ABSTRACT:

Importance

Coxsackievirus A6 (CV-A6) is a major emerging pathogen associated with atypical hand, foot, and mouth disease and can cause serious complications such as encephalitis, acute flaccid paralysis, and neurorespiratory syndrome. Therefore, revealing the associated pathogenic mechanisms could benefit the control of CV-A6 infections. In this study, we demonstrate that the nonstructural 2C_CV-A6 suppresses IFN-β production, which supports CV-A6 infection. This is achieved by depleting RNA sensors such as melanoma differentiation-associated gene 5 and retinoic acid-inducible gene I (RIG-I) through the lysosomal pathway. Such a function is shared by 2C_EV-A71 and 2C_CV-B3 but not 2C_CV-A16, suggesting the latter might have an alternative way

SUBMITTER: Wang S-H 

PROVIDER: S-EPMC10688345 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature