Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.

ABSTRACT: The HIV-1 genome encodes a small number of proteins with structural, enzymatic, regulatory, and accessory functions. These viral proteins interact with a number of host factors to promote the early and late stages of HIV-1 infection. During the early stages of infection, interactions between the viral proteins and host factors enable HIV-1 to enter the target cell, traverse the cytosol, dock at the nuclear pore, gain access to the nucleus, and integrate into the host genome. Similarly, the viral proteins recruit another set of host factors during the late stages of infection to orchestrate HIV-1 transcription, translation, assembly, and release of progeny virions. Among the host factors implicated in HIV-1 infection, Cyclophilin A (CypA) was identified as the first host factor to be packag

SUBMITTER: Padron A 

PROVIDER: S-EPMC10688351 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature