Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease.

ABSTRACT:

Background

Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's disease (AD), Parkinson's disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result in endo-lysosomal system dysfunction and an age-dependent increase in the expression of another protein associated with NDs, glycoprotein non-metastatic B (GPNMB).

Main body

It is unclear what role GPNMB plays in the context of PGRN insufficiency and how they interact and contribute to the development or progression of NDs. This review focuses on the interplay between these two critical proteins within the context of endo-lysosomal health, immune function, and inflammation in their

SUBMITTER: Gillett DA 

PROVIDER: S-EPMC10688479 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature