Specific expression profile of follicular fluid-derived exosomal microRNAs in patients with diminished ovarian reserve.

ABSTRACT:

Background

Diminished ovarian reserve (DOR) is defined as a reduction in ovarian reserve and oocyte quality. The pathophysiology of DOR has not been completely explained as of yet. Scholars have uncovered a large number of exosomes that have been detected in follicular fluid, and exosomal miRNAs have been proven to play a critical role in controlling ovarian disorders and follicle formation. We focused on the expression profile of follicular fluid-derived exosomal microRNAs (miRNAs) and attempted to understand if their role is connected to the pathomechanism of DOR.

Methods

The follicular fluid-derived differentially expressed exosomal miRNAs (DEmiRs) between patients with DOR and those with normal ovarian function were investigated using the next-generation sequencing (NGS)

SUBMITTER: Shen KY 

PROVIDER: S-EPMC10688486 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature