Connections between cross-tissue and intra-tissue biomarkers of aging biology in older adults.

ABSTRACT:

Background

Saliva measures are generally more accessible than blood, especially in vulnerable populations. However, connections between aging biology biomarkers in different body tissues remain unknown.

Methods

The present study included individuals (N = 2406) who consented for saliva and blood draw in the Health and Retirement Telomere length study in 2008 and the Venous blood study in 2016 who had complete data for both tissues. We assessed biological aging based on telomere length in saliva and DNA methylation and physiology measures in blood. DNA methylation clocks combine information from CpGs to produce the aging measures representative of epigenetic aging in humans. We analyzed DNA methylation clocks proposed by Horvath (353 CpG sites), Hannum (71 CpG sites), L

SUBMITTER: Waziry R 

PROVIDER: S-EPMC10688599 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature