Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.

ABSTRACT:

Introduction

Hepatic fibrosis is a progressive pathological process involving the exhaustion of hepatocellular regenerative capacity and ultimately leading to the development of cirrhosis and even hepatocellular carcinoma. Brg1, the core subunit of the SWI/SNF chromatin-remodeling complex, was recently identified as important for liver regeneration. This study investigates the role of Brg1 in hepatic fibrosis development.

Methods

Hepatocyte-specific Brg1 knockout mice were generated and injected with carbon tetrachloride (CCl4) for 4, 6, 8, and 12 weeks to induce liver fibrosis. Afterwards, liver fibrosis and liver damage were assessed.

Results

Brg1 expression was significantly increased in the fibrotic liver tissue of wild-type mice, as compared to that of untreated

SUBMITTER: Wang B 

PROVIDER: S-EPMC10688683 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature