Probiotic colonization dynamics after oral consumption of VSL#3^® by antibiotic-treated mice.

ABSTRACT: Background: The ability of probiotic strains to provide health benefits to the host partially hinges on the survival of gastrointestinal passage and temporary colonization of the digestive tract. This study aims to investigate the colonization profile of individual probiotic strains comprising the commercial product VSL#3^® and determine their impact on the host intestinal microbiota. Methods: Using a cefoperazone-treated mouse model of antibiotic treatment, we investigated the impact of oral gavage with ~10⁸ CFU commercial VSL#3^® product on the intestinal microbiota using 16S-based amplicon sequencing over 7 days. Results: Results showed that probiotic strains in the formulation were detected in treated murine fecal samples, with early

SUBMITTER: Theriot C 

PROVIDER: S-EPMC10688816 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature