Management of Helicobacter pylori treatment failures: A large population-based study (HP treatment failures trial).

ABSTRACT:

Background

Helicobacter pylori treatment failure remains a challenging problem. This study aimed to identify predictive factors for successful eradication in patients following treatment failures.

Methods

This was a retrospective cohort study. This study included 1,050 dyspeptic patients diagnosed with H. pylori infection at tertiary care center in Thailand between March 2014 and October 2021. Patients' demographic data, endoscopic findings, H. pylori culture, antimicrobial susceptibility testing (AST), treatment regimens and outcomes were analysed.

Results

Of 1,050 patients with H. pylori infections, 302 (28.7%) experienced treatment failure (mean age 58.4 years; 44.7% males). AST was performed in 192. Resistance was observed for metronidazole (43.2%), levofloxacin (

SUBMITTER: Aumpan N 

PROVIDER: S-EPMC10688878 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature