XRE transcription factors conserved in Caulobacter and φCbK modulate adhesin development and phage production.

ABSTRACT: The xenobiotic response element (XRE) family of transcription factors (TFs), which are commonly encoded by bacteria and bacteriophage, regulate diverse features of bacterial cell physiology and impact phage infection dynamics. Through a pangenome analysis of Caulobacter species isolated from soil and aquatic ecosystems, we uncovered an apparent radiation of a paralogous XRE TF gene cluster, several of which have established functions in the regulation of holdfast adhesin development and biofilm formation in C. crescentus. We further discovered related XRE TFs throughout the class Alphaproteobacteria and its phages, including the φCbK Caulophage, suggesting that members of this cluster impact host-phage interactions. Here we show that a closely related group of XRE transcription factors enc

SUBMITTER: McLaughlin M 

PROVIDER: S-EPMC10688885 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature