Chromosome-specific maturation of the epigenome in the <i>Drosophila</i> male germline.

ABSTRACT: Spermatogenesis in the Drosophila male germline proceeds through a unique transcriptional program controlled both by germline-specific transcription factors and by testis-specific versions of core transcriptional machinery. This program includes the activation of genes on the heterochromatic Y chromosome, and reduced transcription from the X chromosome, but how expression from these sex chromosomes is regulated has not been defined. To resolve this, we profiled active chromatin features in the testes from wildtype and meiotic arrest mutants and integrate this with single-cell gene expression data from the Fly Cell Atlas. These data assign the timing of promoter activation for genes with germline-enriched expression throughout spermatogenesis, and general alterations of

SUBMITTER: Anderson JT 

PROVIDER: S-EPMC10688970 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature