Urinary albumin excretion and cancer risk: the PREVEND cohort study.

ABSTRACT:

Background

Chronic kidney disease (CKD) is believed to be associated with an increased risk for cancer, especially urinary tract cancer. However, previous studies predominantly focused on the association of decreased estimated glomerular filtration rate (eGFR) with cancer. In this study, we investigated the association of albuminuria with cancer incidence, adjusted for eGFR.

Methods

We included 8490 subjects in the Prevention of Renal and Vascular End-stage Disease (PREVEND) observational study. Urinary albumin excretion (UAE) was measured in two 24-hour urine specimens at baseline. Primary outcomes were the incidence of overall and urinary tract cancer. Secondary outcomes were the incidence of other site-specific cancers, and mortality due to overall, urinary tract, and oth

SUBMITTER: Luo L 

PROVIDER: S-EPMC10689183 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature