Estimating the global impact of rotavirus vaccines on child mortality.

ABSTRACT:

Objectives

We estimated the global impact of rotavirus vaccines on deaths among children under five years old by year.

Methods

We used a proportionate outcomes model with a finely disaggregated age structure to estimate rotavirus deaths prevented by vaccination over the period 2006-2019 in 186 countries. We ran deterministic and probabilistic uncertainty analyses and compared our estimates to surveillance-based estimates in 20 countries.

Results

We estimate that rotavirus vaccines prevented 139,000 under-five rotavirus deaths (95% uncertainty interval 98,000-201,000) in the period 2006-2019. In 2019 alone, rotavirus vaccines prevented 15% (95% uncertainty interval 11-21%) of under-five rotavirus deaths (0.5% of child mortality). Assuming global use of rotavirus vaccin

SUBMITTER: Clark A 

PROVIDER: S-EPMC10689250 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature