Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders.

ABSTRACT:

Background

Maternal inflammation can result from immune dysregulation and metabolic perturbations during pregnancy. Whether conditions associated with inflammation during pregnancy increase the likelihood of autism spectrum disorder (ASD) or other neurodevelopmental disorders (DDs) is not well understood.

Methods

We conducted a case-control study among children born in California from 2011 to 2016 to investigate maternal immune-mediated and cardiometabolic conditions during pregnancy and risk of ASD (n = 311) and DDs (n = 1291) compared with children from the general population (n = 967). Data on maternal conditions and covariates were retrieved from electronic health records. Maternal genetic data were used to assess a causal relationship.

Results

SUBMITTER: Croen LA 

PROVIDER: S-EPMC10689278 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature