Contribution of the SOS response and the DNA repair systems to norfloxacin induced mutations in E. coli.

ABSTRACT: Antibiotic-resistant bacteria severely threaten human health. Besides spontaneous mutations generated by endogenous factors, the resistance might also originate from mutations induced by certain antibiotics, such as the fluoroquinolones. Such antibiotics increase the genome-wide mutation rate by introducing replication errors from the SOS response pathway or decreasing the efficiency of the DNA repair systems. However, the relative contributions of these molecular mechanisms remain unclear, hindering understanding of the generation of resistant pathogens. Here, using newly-accumulated mutations of wild-type and SOS-uninducible Escherichia coli strains, as well as those of the strains deficient for the mismatch repair (MMR) and the oxidative damage repair pathways, we find that the S

SUBMITTER: Lin T 

PROVIDER: S-EPMC10689325 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature