Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1^-/y mouse model of autism.

ABSTRACT: Excessive neural variability of sensory responses is a hallmark of atypical sensory processing in autistic individuals with cascading effects on other core autism symptoms but unknown neurobiological substrate. Here, by recording neocortical single neuron activity in a well-established mouse model of Fragile X syndrome and autism, we characterized atypical sensory processing and probed the role of endogenous noise sources in exaggerated response variability in males. The analysis of sensory stimulus evoked activity and spontaneous dynamics, as well as neuronal features, reveals a complex cellular and network phenotype. Neocortical sensory information processing is more variable and temporally imprecise. Increased trial-by-trial and inter-neuronal response variability is strongly related to

SUBMITTER: Bhaskaran AA 

PROVIDER: S-EPMC10689491 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature