Copy number variants and fetal structural abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study.

ABSTRACT:

Objective

To examine the association of placental and fetal DNA copy number variants (CNVs) with fetal structural malformations (FSMs) in stillborn fetuses.

Design

A secondary analysis of stillbirth cases in the Stillbirth Collaborative Research Network (SCRN) study.

Setting

Multicenter, 59 hospitals in five geographic regions in the USA.

Population

388 stillbirth cases of the SCRN study (2006-2008).

Methods

Fetal structural malformations were grouped by anatomic system and specific malformation type (e.g. central nervous system, thoracic, cardiac, gastrointestinal, skeletal, umbilical cord and craniofacial defects). Single-nucleotide polymorphism array detected CNVs of at least 500 kb. CNVs were classified into two groups: normal, defined as no CNVs >50

SUBMITTER: Workalemahu T 

PROVIDER: S-EPMC10689565 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature