Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews.

ABSTRACT:

Introduction

Most Alzheimer's disease (AD) loci have been discovered in individuals with European ancestry (EA).

Methods

We applied principal component analysis using Gaussian mixture models and an Ashkenazi Jewish (AJ) reference genome-wide association study (GWAS) data set to identify Ashkenazi Jews ascertained in GWAS (n = 42,682), whole genome sequencing (WGS, n = 16,815), and whole exome sequencing (WES, n = 20,504) data sets. The association of AD was tested genome wide (GW) in the GWAS and WGS data sets and exome wide (EW) in all three data sets (EW). Gene-based analyses were performed using aggregated rare variants.

Results

In addition to apolipoprotein E (APOE), GW analyses (1355 cases and 1661 controls) revealed associations with TREM2 R47H (p = 9.66 × 10

SUBMITTER: Li D 

PROVIDER: S-EPMC10689571 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature