PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.

ABSTRACT: Dopamine neurons are essential for voluntary movement, reward learning, and motivation, and their dysfunction is closely linked to various psychological and neurodegenerative diseases. Hence, understanding the detailed signaling mechanisms that functionally modulate dopamine neurons is crucial for the development of better therapeutic strategies against dopamine-related disorders. Phospholipase Cγ1 (PLCγ1) is a key enzyme in intracellular signaling that regulates diverse neuronal functions in the brain. It was proposed that PLCγ1 is implicated in the development of dopaminergic neurons, while the physiological function of PLCγ1 remains to be determined. In this study, we investigated the physiological role of PLCγ1, one of the key effector enzymes in intracellular signaling, in regulating

SUBMITTER: Kim HY 

PROVIDER: S-EPMC10689754 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature