Coevolution between marine Aeromonas and phages reveals temporal trade-off patterns of phage resistance and host population fitness.

ABSTRACT: Coevolution of bacteria and phages is an important host and parasite dynamic in marine ecosystems, contributing to the understanding of bacterial community diversity. On the time scale, questions remain concerning what is the difference between phage resistance patterns in marine bacteria and how advantageous mutations gradually accumulate during coevolution. In this study, marine Aeromonas was co-cultured with its phage for 180 days and their genetic and phenotypic dynamics were measured every 30 days. We identified 11 phage resistance genes and classified them into three categories: lipopolysaccharide (LPS), outer membrane protein (OMP), and two-component system (TCS). LPS shortening and OMP mutations are two distinct modes of complete phage resistance, while TCS mutants mediate incomple

SUBMITTER: Xu Z 

PROVIDER: S-EPMC10689771 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature