Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy.

ABSTRACT: Solid tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth. Angiogenesis and immune suppression are two key characteristics of this tumor microenvironment. Despite attempts to deplete tumor blood vessels using antiangiogenic drugs, extensive vessel pruning has shown limited efficacy. Instead, a targeted approach involving the judicious use of drugs at specific time points can normalize the function and structure of tumor vessels, leading to improved outcomes when combined with other anticancer therapies. Additionally, normalizing the immune microenvironment by suppressing immunosuppressive cells and activating immunostimulatory cells has shown promise in suppressing tumor growth and improving overall survival. Based

SUBMITTER: Choi Y 

PROVIDER: S-EPMC10689787 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature