Left ventricular underfilling in PAH: A potential indicator for adaptive-to-maladaptive transition.

ABSTRACT: Pulmonary arterial hypertension (PAH) still remains a life-threatening disorder with poor prognosis. The right ventricle (RV) adapts to the increased afterload by a series of prognostically significant morphological and functional changes, the adaptive nature should also be understood in the context of ventricular interdependence. We hypothesized that left ventricle (LV) underfilling could serve as an important imaging marker for identifying maladaptive changes and predicting clinical outcomes in PAH patients. We prospectively enrolled patients with PAH who underwent both cardiac magnetic resonance and right heart catheterization between October 2013 and December 2020. Patients were categorized into four groups based on their LV and RV mass/volume ratio (M/V). LV M/V was stratified using t

SUBMITTER: Guo J 

PROVIDER: S-EPMC10689890 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature