Swedish multicentre study of target attainments with β-lactams in the ICU: which MIC parameter should be used?

ABSTRACT:

Background

Therapeutic drug monitoring (TDM) has been suggested to optimize antimicrobial target attainment, typically using 100%T>MIC, in β-lactam treatment in the ICU. The MIC parameter used in this equation is mostly the worst case scenario MIC (MICWCS)-the highest MIC the empirical treatment should cover. However, the impact of the MIC parameter used in pharmacokinetic/pharmacodynamic calculations has been poorly investigated.

Objectives

To assess the influence of target attainment rates for two different MIC parameters using actual MICs of the causative pathogens as the primary reference.

Methods

In a Swedish multicentre study of target attainment for 138 ICU patients treated with β-lactams, the causative pathogen was isolated and subjected to reference MIC testi

SUBMITTER: Smekal AK 

PROVIDER: S-EPMC10689903 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature