Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.

ABSTRACT: The relationship between clinically accessible epileptic biomarkers and neuronal activity underlying the transition to seizure is complex, potentially leading to imprecise delineation of epileptogenic brain areas. In particular, the pattern of interneuronal firing at seizure onset remains under debate, with some studies demonstrating increased firing and others suggesting reductions. Previous study of neocortical sites suggests that seizure recruitment occurs upon failure of inhibition, with intact feedforward inhibition in non-recruited territories. We investigated whether the same principle applies in limbic structures. We analysed simultaneous electrocorticography (ECoG) and neuronal recordings of 34 seizures in a cohort of 19 patients (10 male, 9 female) undergoing surgical evaluation

SUBMITTER: Agopyan-Miu AH 

PROVIDER: S-EPMC10689922 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature