Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis.

ABSTRACT: Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in cognitive function and mental health. Recent research has positioned the gut microbiota as an important susceptibility factor in Alzheimer's disease by showing specific alterations in the gut microbiome composition of Alzheimer's patients and in rodent models. However, it is unknown whether gut microbiota alterations are causal in the manifestation of Alzheimer's symptoms. To understand the involvement of Alzheimer's patient gut microbiota in host physiology and behaviour, we transplanted faecal microbiota from Alzheimer's patients and age-matched healthy controls into microbiota-depleted young adult rats. We found impairments in behaviours reliant on adult hippocampal neurogenesis, an essential process for

SUBMITTER: Grabrucker S 

PROVIDER: S-EPMC10689930 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature