Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings.

ABSTRACT: Age is a dominant risk factor for some of the most common neurological diseases. Biological ageing encompasses interindividual variation in the rate of ageing and can be calculated from clinical biomarkers or DNA methylation data amongst other approaches. Here, we tested the hypothesis that a biological age greater than one's chronological age affects the risk of future neurological diagnosis and the development of abnormal signs on clinical examination. We analysed data from the Swedish Adoption/Twin Study of Aging (SATSA): a cohort with 3175 assessments of 802 individuals followed-up over several decades. Six measures of biological ageing were generated: two physiological ages (created from bedside clinical measurements and standard blood tests) and four blood methylation age measures. T

SUBMITTER: McMurran CE 

PROVIDER: S-EPMC10690013 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature